Bioactive Marine Natural Products is the first book available that covers all aspects of bioactive marine natural products. It fills the void in the literature for bioactive marine natural products. The book covers various aspects of marine natural products and it is hoped that all the major classes of bioactive compounds are included.
Different classes of marine organisms and the separation and isolation techniques are discussed. The chemistry and biology of marine toxins, peptides, alkaloids, nucleosides and prostanoids are discussed in detail. Biological, toxicological and clinical evaluations are also dealt with to ensure that the book may be adopted at any stage by any practicing organic chemist or biologist, working in academia or in R and D divisions of pharmaceutical companies.
Each chapter in the book includes an abstract to highlight the major points discussed in the text and concluding remarks are given. References to books, monographs, review articles and original papers are provided at the end of each chapter.
This two volume reference work begins with a section that provides a taxonomic survey of the secondary metabolites of diverse marine life including microbes, algae, and invertebrates. This is followed by a demonstration of the techniques and strategies employed in modern structure elucidation of complex natural products.
The natural roles of marine natural products are then explored in a series of focused chapters which include the topics of symbiosis, anti-predation and antifouling, chemical interactions, and defence against UV stress. Various routes which facilitate the understanding of marine natural product biosynthesis are subsequently explained and these are followed by an extensive set of chapters on the biomedical potential of marine natural products.
The latter portion of this section considers the technologies and scientific disciplines necessary for advancing bioactive marine natural product lead compounds into actual pharmaceuticals. The reference work finishes with a selection of chapters describing marine toxins and their impact on public health and seafood resources.
Final thoughts presented at the end of the second volume focus on the future of this field of investigation and discovery research. This publication is presented as a reference handbook and general concepts are emphasized and illustrated with numerous interesting examples, graphical information, and a comprehensive index.
It is an ideal desk companion for courses focusing on this contemporary area. The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters.
Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new drugs with improved properties over their progenitors. The examples are chosen so as to represent a wide range of natural products with therapeutic relevance among others, as anticancer agents, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics. Natural products continue to serve as sources for the development of new medicines.
There is currently a revival of interest in the discovery of bioactive compounds with new chemical structures from natural sources, largely due to the fact that synthetic libraries have not yielded the expected number of developmental candidates in the pharmaceutical industry during the last decade.
In addition, the emergence of clinically relevant pathogens that are becoming increasingly resistant to currently used medicines strengthens the notion that natural product research is urgently required.
This new volume, Health Benefits of Secondary Phytocompounds from Plant and Marine Sources, looks at a selection of important issues and research topics on phytochemicals in plant-based therapeutics, covering bioactive compounds from both plant and marine sources. Natural products and their bioactive compounds are increasingly utilized in preventive and therapeutic medication, as pharmaceutical supplements, as well as in functional foods and nutraceuticals, all of which have potentially positive effects on health and have preventive and curative properties for various diseases and health conditions.
The first section of the book, on Bioactive Compounds from Plant Sources, describes the concept of extraction of bioactive molecules from plant sources, both conventional and modern extraction techniques, available sources, biochemistry, structural composition, and potential biological activities. Advanced extraction techniques, such as enzyme-assisted, microwave-assisted, ultrasound-assisted, pressurized liquid extraction, and super critical extraction techniques, are described in detail.
During the past 20 years, marine chemical ecology has emerged as a respected field of study providing a better understanding of the role natural products play in organisms and their environments. Ample data in this book advocates the conservation of marine environments for future drug discovery efforts while sustaining their overall health. Marine chemical ecology has expanded to include research in the areas of predator—prey interactions, marine microbial chemical ecology, and seasonal and geographical distribution of marine natural products.
Marine Natural Products: Chemical and Biological Perspectives, Volume I, reviews the state of knowledge in the chemistry and biology of marine natural products. It brings together critical reviews and new perspectives for the marine research community. The book's opening chapter discusses the isolation, distribution, chemistry, pharmacology, and public health aspects of dinoflagellate toxins.
This is followed by separate chapters on algal nonisoprenoids, algal sesquiterpenoids, terpenoids from marine sponges, and uncommon marine steroids. Marine Natural Products: Chemical and Biological Perspectives, Volume II, reviews the state of knowledge in the chemistry and biology of marine natural products.
It attempts to bring together timely and critical reviews that are representative of major current researches and that, hopefully, will also foreshadow future trends. The first three chapters of this volume deal with marine carotenoids, steroids, and diterpenoids.
This is followed by a chapter that examines a single phylum, the Coelenterata, and its metabolites. The Coelenterata is an almost exclusively marine phylum of some described living species. Research predicts that the coelenterates will yield a rich harvest of organic metabolites.
The final chapter, which focuses on 13C NMR spectroscopy for structural elucidation, reveals the power of this instrumental method especially when applied to the difficult problems of polyhalogenated marine metabolites. This 8-volume set provides a systematic description on 8, active marine natural products from 3, various kinds of marine organisms.
The diversity of structures, biological resources and pharmacological activities are discussed in detail. Molecular structural classification system with structural types are developed as well.
The 5th volume mainly illustrates the molecular formula and structures of polyketides and steroids. Natural compounds, which have evolved their function over millions of years, are often more efficient than man-made compounds if a specific biological activity is needed, e.
This book comprising of sixteen technical chapters, highlights the chemical and biological aspects of potential natural products with an intention of unravelling their pharmaceutical applicability in modern drug discovery processes. The interdisciplinary field of marine chemical ecology is an expanding and dynamic science. It is no surprise that the breadth of marine organisms studied expanded in concert with developments in underwater technology. With its up-to-date subject reviews by experts, Marine Chemical Ecology is the most current, comprehensive book on the subject.
Two review papers, eight research articles, and one brief report were published in this Special Issue. They showed the rich resources that are present within the genomes of marine microorganisms and discussed the use of recently developed tools and technologies to exploit this genetic richness.
This review highlights recent findings of our group on bioactive marine natural products isolated from marine sponges and marine derived fungi. The activated chemical defence of the Mediterranean sponge Aplysina aerophoba is introduced as an example of a dynamic response of marine sponges to wounding. Following tissue disrupture preformed brominated isoxazoline alkaloids are enzymatically.
Page Buck, E. Copeland, J. Zinn, and D. Natural Products Isolation-G. Wagman This new book encompasses, in great detail, the most recent progress made in the isolation and separation of natural products.
It covers antibiotics, marine and plant-derived substances, enzyme inhibitors and interferons. The most recent separation methodology is described. Outline 1. Very important terms of coordination chemistry 2.
General aspects of bioinorganic chemistry 3. Kaim, B.
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